Record Display for the EPA National Library Catalog


Main Title A biologic indicator for air pollution /
Author Sherwin, Russell P.
CORP Author Los Angeles County-Univ. of Southern California Medical Center.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory ; For sale by the National Technical Information Service,
Year Published 1979
Report Number EPA 600/1-79/038; EPA-R-800881; EPA-R-804545
Stock Number PB80-143274
OCLC Number 37860107
Subjects Nitrogen dioxide--Physiological effect ; Air--Pollution--Physiological effect
Additional Subjects Indicator species ; Nitrogen dioxide ; Exposure ; Guinea pigs ; Mice ; Laboratory animals ; Cells(Biology) ; Protein ; Lung ; Air pollution ; Electrophoresis ; Kinetics ; Ultraviolet radiation ; Bioindicators ; Air pollution effects(Animals)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-79-038 Headquarters Library/Washington,DC 04/21/2014
EJBD  EPA 600-1-79-038 c.1 Headquarters Library/Washington,DC 04/28/2014
EKBD  EPA-600/1-79-038 Research Triangle Park Library/RTP, NC 06/01/2001
ELBD  EPA 600-1-79-038 AWBERC Library/Cincinnati,OH 11/15/2016
NTIS  PB80-143274 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xi, 71 pages : illustrations ; 28 cm
The report describes studies wherein guinea pigs and mice were exposed to low levels of nitrogen dioxide either continuously or on an intermittent schedule. The major objective was to develop highly sensitive discriminants involving correlations of structural and functional alterations. The two major test areas developed were the quantitative measurements of Type 2 cell populations and protein leakage within the lung. The increase in number and size of Type 2 pneumocytes with NO2 exposure is believed to represent a corresponding loss of Type 1 lung cells, and the protein leakage within the lung is in accord with the concept that the Type 1 cell is a critical barrier for fluid transport in the alveolar area. The authors suggest that their research data supports the hypothesis that to properly evaluate the possible health effects from air pollutants one must give attention to the subclinical cellular alterations that deplete the functional and structural reserves of organs which are the primary target for air pollutants.
Grants no. R800881 and R804545. "EPA-600/1-79-038." Project officer: Donald E. Gardner. Includes bibliographical references (pages 68-70).