| Main Title |
Pyrethroid Effects on Schedule-Controlled Behavior: Time and Dosage Relationships (Journal Version). |
| Author |
Peele, D. B. ;
Crofton, K. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/421; |
| Stock Number |
PB89-105860 |
| Additional Subjects |
Insecticides ;
Pyrethrins ;
Toxic substances ;
Toxicity ;
Animal behavior ;
Laboratory animals ;
Chlorine organic compounds ;
Operant conditioning ;
Dose-response relationships ;
Reprints ;
Permethrin ;
Cypermethrin
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105860 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) were made. Long-Evans rats responded for food according to a multiple schedule consisting of four different variable-interval schedules. Permethrin (100-400 mg/kg) and cypermethrin (7.5-60 mg/kg) were administered po 1.5 hrs pre-session and their effects on response rates and between-component response patterning determined. Differential effects on response patterning, in potency, and in the time course of effects of permethrin and cypermethrin suggest a type-specificity for pyrethroid effects on schedule-controlled behavior at dosages far below those producing lethality in rats. (Copyright (c) Pergamon Journals Ltd., 1987.) |
