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RECORD NUMBER: 479 OF 846

Main Title Letter from Mobil Oil Corporation to USEPA Submitting Laboratory Results on Dimethyl Hydrogen Phosphite.
CORP Author Mobil Oil Corp., New York.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 3 Oct 1980
Year Published 1980
Report Number 8HEQ-1080-0366;
Stock Number OTS-0204866
Additional Subjects Toxicity ; Laboratory tests ; Mutagenicity tests ; Cataracts ; Vapors ; Rats ; Lymphoma ; Exposure(Physiology) ; Chemical analysis ; Industrial hygiene ; Ophthalmology ; US EPA ; Screening ; Dimethyl hydrogen phosphite ; Mobil Oil Corporation
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NTIS  OTS-0204866 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 217p
Abstract
The Mobil Research and Development Corporation has submitted summarized results from several laboratory studies of dimethyl hydrogen phosphate (CAS No. 868-85-9). According to the submitter, the chemical was found to be positive in two of five short-term mutagenicity screening tests. In addition, the submitter reported that cataracts and 'other toxic effects' were observed in rats exposed (subacutely) to dimethyl hydrogen phosphate at high vapor concentrations (i.e., 119 and 198 ppm). Milder forms of lens opacities were reportedly observed in rats that although no clinical cataracts were found in a previously performed ophthalmological study of plant employees, including those involved with the manufacture of dimethyl hydrogen phosphate, a reanalysis of the original data will be conducted 'to determine whether there may be a statistically significant number of subclinical opacities among the dimethyl hydrogen phosphate segment of the plant population'.