Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Ozone on Human Immunity: In vitro Responsiveness of Lymphocytes to Phytohemmagglutinin.
Author Peterson, Mirzda L. ; Rummo, Nicholas ; House, Dennis ; Harder., Shirley ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div.
Year Published 1976
Report Number EPA/600/J-78/025;
Stock Number PB-284 764
Additional Subjects Ozone ; Immunity ; Toxicology ; Humans ; Lymphocytes ; Blood cells ; Exposure ; In vitro analysis ; Responses ; Air pollution ; Physiological effects ; Reprints ; Toxic substances ; Plant agglutinins ; Immunosuppression ; Environmental health ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-284 764 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 7p
Peripheral blood lymphocytes from 20 human subjects exposed to 784 micrograms cu m ozone for 4 hours, and from 11 subjects exposed to clean air for the same length of time were studied for in vitro responsiveness to phytohemagglutinin (PHA). Thymus-derived (T) lymphocyte response to PHA (normal response is proliferation of lymphocytes) was significantly suppressed (P<.01) in samples obtained immediately after subjects' exposure to ozone. Recovery of response occurred 2 weeks postexposure. Responses were unchanged in subjects exposed to clean air. The significance of the suppression of T-cell response noted in this study is that (1) if continuous exposures to ozone are shown to induce an immunosuppressed state for a significant time period, an important factor in carcinogenesis might be elucidated; (2) immunosuppression may cause a progression of an already present tumor; (3) immunosuppression may enable endogenous latent infection such as tuberculosis to reactivate; and (4) immunosuppression may explain in part the relationship between chronic oxidant air pollution and influenza-like illnesses in population.