Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment.
Author Schoor, W. P. ; Williams, D. E. ; Takahashi., N. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Oregon State Univ., Corvallis. Dept. of Food Science and Technology.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/342;
Stock Number PB92-129790
Additional Subjects Water pollution effects(Animals) ; Cytochrome P-450 ; Sediments ; Poecilia ; Creosote ; Liver ; Pathology ; Mixed function oxidases ; Enzyme induction ; Immunohistochemistry ; Liquid chromatography ; Carcinogens ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-129790 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/28/1992
Collation 10p
Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.