Record Display for the EPA National Library Catalog


Main Title Mycoplasma genitalium Protein Resembling the 'Mycoplasma pneumoniae' Attachment Protein.
Author Hu, P. C. ; Schaper, U. ; Collier, A. M. ; Clyde, W. A. ; Horikawa., M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Food and Drug Administration, Bethesda, MD. Center for Drugs and Biologics.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/537;
Stock Number PB91-116061
Additional Subjects Humans ; Electron microscopy ; Reprints ; Bacterial proteins ; Mycoplasma pneumoniae ; Mycoplasma genitalium ; Cross reactions ; Immune sera ; Monoclonal antibodies ; Antigenic determinants ; Autoradiography ; Western blotting
Library Call Number Additional Info Location Last
NTIS  PB91-116061 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
In previous studies with hyperimmune rabbit sera and monoclonal antibodies against P1 protein of M. pneumoniae, evidence was obtained of a shared antigenic determinant with a single protein of M. genitalium. Because of biological and morphological similarities between these two human Mycoplasma species, attempts were made to characterize this cross-reacting protein of M. genitalium (designated MgPa). The protein was surface exposed, and had an estimated molecular weight of 140 K daltons. Electron microscopy using monoclonal antibodies produced against either MgPa or P1 demonstrated that MgPa is located over the surface of the terminal structure of M. genitalium which is covered by a nap layer. These immunologic and morphologic findings suggest that the MgPa protein of M. genitalium could be the counterpart of the P1 protein of M. pneumoniae. (Copyright (c) 1987, American Society for Microbiology.)