Record Display for the EPA National Library Catalog


Main Title Development of the Linkage of Beta-Adrenergic Receptors to Cardiac Hypertrophy and Heart Rate Control: Neonatal Sympathectomy with 6-Hydroxydopamine.
Author Hou, Q. C. ; Seidler, F. J. ; Slotkin, T. A. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-813769; EPA/600/J-89/379;
Stock Number PB90-216201
Additional Subjects Hypertrophy ; Heart diseases ; Heart rate ; Body weight ; Nerve cells ; Graphs(Charts) ; Reprints ; Hydroxydopamines ; Adrenergic beta receptors ; Chemical sympathectomy ; Newborn animals ; Organ weight ; Isoproterenol
Library Call Number Additional Info Location Last
NTIS  PB90-216201 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Presynaptic neural projections are thought to participate in the maturation of postsynaptic sensitivity to neurotransmitters. In the current study, the effects of sympathectomy with 6-hydroxydopamine on the ontogeny of the linkage of beta-adrenergic receptors to cardiac growth and heart rate control in the rat have been examined. Destruction of sympathetic projections at birth compromised the ability of beta-receptor stimulation to evoke cardiac hypertrophy, a defect which persisted into young adulthood. The chronotropic response to beta-receptor activation, assessed by acute challenge with a submaximally-effective dose of isoproterenol, also exhibited a slowed development, but did eventually achieve normal sensitivity. In contrast, neonatal sympathectomy had only minor effects on resting heart rate, basal heart rate (the intrinsic rate in the absence of autonomic input) or maximal heart rate; these animals also showed beta-receptor desensitization of chronotropic action in response to chronic isoproterenol treatment. (Copyright (c) Oxford University Press 1989.)