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Main Title Letter from Synthetic Organic Chemical Manufactures Assoc. to the USEPA Submitting Information on the Results of a 14 Week Inhalation Study in Rats Exposed to Diethylethanolamine.
CORP Author Synthetic Organic Chemical Manufacturers Association, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 29 Jun 1989
Year Published 1989
Report Number FYI-OTS-0689-0699;
Stock Number OTS-0000699
Additional Subjects Rats ; Inhalation ; Nasal mucosa ; Hypertrophy ; Diethylethanolamine ; Fischer F-344 rats ; Multifocal mixed inflammatory cell infiltration ; Dose-related histologic changes ; Nasal turbinates ; Nasal cavities ; Focal hyperplasia ; Squamous metaplasia ; Respiratory eptihemlium
Library Call Number Additional Info Location Last
NTIS  OTS-0000699 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Fischer F-344 adult rats were exposed to airborne vapor concentrations of 0, 10, 25 or 75 ppm of DEEA for 14 weeks (6 hrs/day x 5 day's wk). Groups of animals were sacrificed immediately following the 14 week exposure as well as after a 4 week post-exposure or recovery period. No exposure-related microscopic changes were observed in any of the rats exposed to 10 ppm whether sacrificed immediately after the 14 week exposure or after a 4 week recovery period. Dose-related histological changes were observed in nasal turbinates and nasal cavities in rats exposed 14 weeks to 25 ppm or to 75 ppm. Such findings consisted of an increased incidence and severity, viz., minimal to slight to moderate, of focal hyperplasia alone and focal hyperplasia with squamous metaplasia of respiratory epithelium and multifocal mixed inflammatory cell infiltration of nasal mucosa. In the 75 ppm group, some rats experienced hypertrophy of goblet cells on the nasal septum and a low incidence of focal necrosis and exudate in the lumen of the nasal cavity.