Record Display for the EPA National Library Catalog


Main Title Health Assessment for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Chapter 6. Carcinogenicity of TCDD in Animals.
Author Lucier, G. ;
CORP Author Syracuse Research Corp., NY. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Aug 92
Year Published 1992
Report Number EPA-68-C0-0043; EPA/600/AP-92/001F ; OHEA-I-486-VOL-6
Stock Number PB93-222701
Additional Subjects Tetrachlorodibenzodioxin ; Dioxins ; Toxicity ; Exposure ; Neoplasms ; Carcinogens ; Bioassay ; Biochemistry ; Hamsters ; Rats ; Mice ; Carcinogenicity ; Aryl hydrocarbon receptors ; Dose-response relationships
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB93-222701 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 73p
Tumor incidence data in experimental animals were available in 1988 to demonstrate that TCDD is a carcinogen at multiple sites in rats and mice. Since 1988, TCDD has been shown to be a carcinogen in hamsters and some of the tumor incidence data in rat liver has been reevaluated. The chapter discusses approaches to risk assessment and recent advances on mechanisms of tumor promotion and dose-response relationships for biochemical and biological events relevant to the carcinogenic actions of dioxin.