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RECORD NUMBER: 10 OF 29

OLS Field Name OLS Field Data
Main Title Genetic Evaluation of Extracts of Dow Corning MDF-0107 Foley Catheter Dispersion in the Ames Bacterial Assay, with Cover Letter dated 04/20/1994.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number OTS-86940001349
Stock Number OTS0558130
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Hexamethyldisiloxane ; Laboratory animals ; Genotoxicity ; Gene mutations ; Bacteria ; In vitro ; CAS No 107-46-0 ; CAS No 70131-67-8
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NTIS  OTS0558130 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/12/2010
Collation 17p
Abstract
The test material was evaluated for genetic activity in a microbial assay (Ames, et al., MUTATION RESEARCH 31:347, 1975) with and without the addition of mammalian metabolic activation. Salmonella typhimurium Str. TA-1535, TA-1537, TA-1538, TA-98, and TA-100 were used as indicator organisms. Dimethy1sulfoxide, absolute ethanol, and sterile physiological saline extracts of the test material prepared by continuous rotary shaking (150 rpm/37C/24 hours) in accordance with the U.S.P. Class VI Plastics Method for biological testing of solid materials, were each introduced into the test system at concentrations of extract ranging from 50 to 3.12pl. A Spot Plate Test against each of the indicator organisms was conducted using the extracts directly on the surface of the agar test plates. No evidence of genetic activity was observed.