Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Genetic Evaluation of Recovered Hexamethyldisiloxane in the Ames Bacterial Assay, with Cover Letter dated 4/20/94.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 86940001361
Stock Number OTS0558142
Additional Subjects Toxicology ; Health effects ; Hexamethyldisiloxane (107-46-0) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-46-0
Library Call Number Additional Info Location Last
NTIS  OTS0558142 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 14p
This study evaluated the mutagenic potential of methyl disiloxane in the Ames assay using Salmonella typhimurium. Mutagenicity was evaluated by measuring the ability of methyl disiloxane to produce reverse mutations in several strains of Salmonella typhimurium (TA1535, TA1537, TA 1538, TA98, TA100) in the presence and absence of Aroclor-induced rat liver microsomal enzymes. The study consisted of two phases. The first phase was the spot plate test in which methyl disiloxane diluted in ethanol was spotted on individual plates of each strain, in the absence or presence of microsomal enzymes. In the second phase, concentrations of 0 (solvent control), 312.5, 625, 1250, 2500, or 5000 ug/plate, along with positive controls, were plated with each tester strain in the presence or absence of microsomal enzymes. Sodium azide, 9-amino acridine, 2-nitrofluorene, and 2-anthramine served as positive controls. No mutagenic responses were produced by the methyl disiloxane in either phase in any strain tested in the absence or presence of microsomal enzymes. Under the conditions of this study, methyl disiloxane was not mutagenic.