Record Display for the EPA National Library Catalog


Main Title Mutational Risks in Females: Genomic Imprinting and Maternal Molecules.
Author Wilson, G. N. ;
CORP Author Texas Univ. Southwestern Medical Center at Dallas. Dept. of Pediatrics.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/181 ; OHEA-R-484
Stock Number PB93-194488
Additional Subjects Mutations ; Females ; Mitochondrial DNA ; Mutagenesis ; Methylation ; Hereditary diseases ; Ribonucleic acids ; Pedigree ; Mitochondria ; Sex chromosomes ; Reprints ; Genomic imprinting
Library Call Number Additional Info Location Last
NTIS  PB93-194488 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Genetic mechanisms for selective mutagenesis in female mammals might include alterations of genomic imprinting, maternally derived molecules, mitochondrial DNA or sex chromosome loci. None of these mechanisms provides an obvious explanation for the higher mutational rates observed for certain mutagens in mouse female pronuclei, but the association of DNA methylation with maternal genomic imprinting is an enticing avenue for research. Further characterization of the extent and homology of genomic imprinting among mammals is required before its relevance to mutagenesis can be determined. The existence of maternal effect mutations in mammals merits evaluation but is not yet proven. The relevance of mitochondrial DNA to female-specific mutagenesis will be greatest in multi-generational studies. (Copyright (c) 1992 Elsevier Science Publishers B.V.)