Record Display for the EPA National Library Catalog


Main Title Interaction between methyl mercury and radiation effects on nervous systems /
Author Hupp, Eugene W. ; Day, Dalton ; Hardcastle, James ; Hines, John ; Minnich., James
Other Authors
Author Title of a Work
Hupp, Eugene W.
Cahill, Daniel F.
CORP Author Texas Woman's Univ., Denton.;Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600/1-77-006; EPA-R-800282; PB265873
Stock Number PB 265 873
OCLC Number 52418631
Subjects Methylmercuric chloride--Physiological effect ; Radiation--Physiological effect ; Rats--Effect of radiation on ; Hamsters--Effect of radiation on ; Monkeys--Effect of radiation on
Additional Subjects Radiation effects ; Nervous system ; Neurology ; Toxicology ; Laboratory animals ; Experimental data ; Rats ; Hamsters ; Monkeys ; Physiology ; Histology ; Brain ; Behavior ; X rays ; Stress(Physiology) ; Synergistic effects ; Mercury/methyl ; Air pollution effects(Animals) ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-77-006 Headquarters Library/Washington,DC 01/17/2014
EKBD  EPA-600/1-77-006 Research Triangle Park Library/RTP, NC 06/13/2003
ELBD ARCHIVE EPA 600-1-77-006 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-265 873 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xii, 118 p. ; 28 cm.
The interaction between methyl mercury and ionizing radiation was investigated in a series of experiments using rats, hamsters, and squirrel monkeys to study the effects produced and possible mechanisms of action. Parameters evaluated included several measurements of behavior, brain electrical activity, lethality, blood-brain barrier permeability, neurotransmitter and mercury concentration in various brain areas, and brain histology. In some cases the effects of the co-insult were less than or at least no greater than at least one of the two insults applied alone. Possible mechanisms of action include opposite effects of the two insults on the blood-brain barrier, with radiation increasing permeability and methyl mercury decreasing it. Radiation may also elicit a proliferation of peroxisome-like organelles which protect against the effects of methyl mercury.
Project Officer: Daniel F. Cahill. Texas Woman's University "January 1977." "EPA-600/1-77-006." Includes bibliographical references.