Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Dermal absorption of 14C-labeled 4,4'-methylenedianiline (4,4'-MDA) in rats, guinea pigs, and monkeys : final report /
Author El-Hawari, M. ; Stoltz, M. ; Czarnecki, D. ; Alm, P.
Other Authors
Author Title of a Work
El-hawari, Monaem.
CORP Author Midwest Research Inst., Kansas City, MO.;Environmental Protection Agency, Washington, DC. Office of Pesticide Programs.
Publisher U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, Field Studies Branch,
Year Published 1986
Report Number 68-02-3938; EPA 560/5-86-011; EPA-68-02-3938; MRI-8501-A(21)
Stock Number PB86-179819
OCLC Number 42843573
Subjects Skin absorption. ; 4,4p1s-methylenedianiline. ; 4,41-methylenedianiline
Additional Subjects Absorption(Biology) ; Skin(Anatomy) ; Rats ; Guinea pigs ; Monkeys ; Laboratory animals ; Measurement ; Therapy ; Dosage ; Methylenedianiline ; Dermal absorption
Internet Access
Description Access URL
Local Library Info
Library Local Subject Local Note
N/A CAS No. 101-77-9 ; (4,4'-MDA); diaminodiphenylmethane; MDA
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 560-5-86-011 Headquarters Library/Washington,DC 05/04/2015
EJBD  EPA 560-5-86-011 Headquarters Library/Washington,DC 05/04/2015
NTIS  PB86-179819 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 1 volume (various pagings) : tables ; 28 cm
To help determine workplace exposure to 4,4'-MDA, studies were performed in male rats, guinea pigs and monkeys treated topically with a low (2 mg/kg) or high (20 mg/kg) dose of 14C-4,4'-MDA. Conditions of treatment (dosage, dose regimens, and occlusion) were assessed. The disposition of 4,4'-MDA was also examined after i.v. dosing. In rats, 43 and 10% of the low dose was recovered in urine and feces during a 96 h period; 2% remained in tissues and skin washing removed 25% of dose. The remainder (26%) was recovered by skin extraction and solubilization. The percent of dose absorbed decreased by increasing the dose, but the total amount absorbed (approx. 0.25 mg/rat) was similar after both doses. In g. pigs, 10 and 18% of the low dose was excreted in urine and feces; 1% was recovered in tissue, 41% in the skin wash and 29% from the application area. The percent of dose absorbed decreased following the high dose, but the amounts absorbed (in mg/animal) doubled.
"January 15, 1986." "EPA Prime Contract no. 68-02-3938." "MRI Project No. 8501-A(21)."