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Main Title Maternal Age Effect: The Enigma of Down Syndrome and Other Trisomic Conditions.
Author Gaulden, M. E. ;
CORP Author Texas Univ. Southwestern Medical Center at Dallas. Dept. of Radiology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/175 ; OHEA-R-478
Stock Number PB93-194421
Additional Subjects Maternal age ; Down syndrome ; Trisomy ; Aneuploidy ; Genetic nondisjunction ; Hormones ; Regional blood flow ; Oxygen ; Carbon dioxide ; Graafian follicle ; Oocytes ; Genetic recombination ; Mutations ; Reprints ; Female genetic risk
Library Call Number Additional Info Location Last
NTIS  PB93-194421 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
Aneuploidy is the most frequently observed chromosome abnormality in human liveborn, abortuses, and oocytes. The only etiological factor that has been established is advanced maternal age for the occurrence of trisomies, particularly trisomy 21 which causes Down syndrome. The maternal age effect remains an enigma. Recent molecular data bearing on this question are reviewed as are the hypotheses that have been proposed linking nondisjunction and maternal age. Rationale is presented for a compromised microcirculation hypothesis that explains the cause of nondisjunction and why its occurrence changes with maternal age. The hypothesis proposes that aneuploid oocytes arise from a concatenation of events.