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Main Title Uptake, Metabolism, and Elimination of 14C-Labeled 1,2,4-Trichlorobenzene in Rainbow Trout and Carp.
Author Melancon, M. J. ; Lech, J. J. ;
CORP Author Medical Coll. of Wisconsin, Inc., Milwaukee.;Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-R-803971; EPA-600/J-80-433;
Stock Number PB84-110667
Additional Subjects Toxicology ; Exposure ; Fishes ; Metabolism ; Reprints ; Rainbow trout ; Carp ; Salmo gairdneri ; Cyrpinus carpio ; Benzene/trichloro ; Labeled substances ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-110667 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Fingerling rainbow trout (Salmo gairdneri) were exposed to 14C-labeled 1,2,4-trichlorobenzene (TCB) for 8 h in a static exposure (0.018 mg/1) or for 35 d in a continuous-flow exposure (0.020 mg/1) followed by a subsequent elimination period. For the 2 d after the 8-h exposure, the half-time (t1/2) of elimination of 14C from muscle and liver was 0.4 d, while after the 35-d exposure an early rapid elimination of 14C from these tissues (t1/2 = 0.4 d) was followed by a slower elimination (t1/2 = 50 d) during d 4-36. The maximum bioconcentration factors for 14C in muscle and liver were 51 and 102 after the 8-h exposure and 89 and 389 during the 35-d exposure. The values for bile were much greater, reaching 240 after the 8-h exposure and 1400 during the 35-d exposure. When larger trout and carp (Cyrpinus carpio) were exposed to (14C)TCB (0.2-0.4 mg/1) the bioconcentration factor for bile 14C to water 14C was less than 100.