Record Display for the EPA National Library Catalog


Main Title Developmental Anomalies Derived from Exposure of Zygotes and First-Cleavage Embryos to Mutagens.
Author Rutledge, J. C. ; Generoso, W. M. ; Shourbaji, A. ; Cain, K. T. ; Gans, M. ;
CORP Author Washington Univ., Seattle. School of Medicine. ;Oak Ridge National Lab., TN. ;University of North Texas, Denton. Dept. of Biology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;Department of Energy, Washington, DC.
Publisher c1992
Year Published 1992
Report Number DE-AC05-84OR21400; EPA/600/J-93/182 ; OHEA-R-485
Stock Number PB93-194496
Additional Subjects Embryos ; Congenital abnormalities ; Mutagens ; Zygote ; Fetal death ; Preimplantation phase ; Hydrops fetalis ; Females ; Mice ; Chromosome aberrations ; Humans ; Biological radiation effects ; Reprints ; Female genetic risk
Library Call Number Additional Info Location Last
NTIS  PB93-194496 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Results of continuing studies indicate that the mouse zygote and two-cell embryo stages are a window of susceptibility in the experimental induction of congenital anomalies with certain mutagenic agents. The mechanisms by which the mutagens initiate the pathogenesis of these developmental defects are not known. However, in certain cases there is evidence that a nonconventional, perhaps epigenetic, mechanism is involved. Detailed characterization of the spectrum of anomalies induced and comparison of responses at the various stages exposed allowed classification of the mutagens generally into two groups. One group is characterized by being effective only in the early stages of zygote development and capable of producing a relatively high incidence of fetal death and hydrops. The other group affects all of the zygote stages studied as well as the two cell-embryo, but does not increase the incidence of fetal death and hydrops. Except for hydrops, chemicals in the two groups do not differ in terms of the types of anomalies present among malformed live fetuses, which bear a resemblance to a subset of common, sporadic human developmental anomalies that are of unknown etiology. This similarity raises the possibility that certain human developmental defects may have their origins in events that happen in the zygote and early pre-implantation stages. (Copyright (c) 1992 Elsevier Science Publishers B.V.)