Record Display for the EPA National Library Catalog


Main Title Chronic Oral Toxicity and Carcinogenicity Study with Formal Dehyde in Rats, Pharmacokinetics and Metabolism of Ingested and Inhaled Formaldehyde with Cover Letter dated 04/19/88.
CORP Author CanTox, Inc., Ontario, Canada. ;Hoechst Celanese Corp., Summit, NJ.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 5 May 1988
Year Published 1988
Report Number FYI-OTS-0588-0612;
Stock Number OTS-0000612-0
Additional Subjects Metabolism ; Pharmacokinetics ; Formaldehyde ; Diets ; Ingestion ; Inhalation ; Blood ; Foods ; Chemical analysis ; Toxicity ; Rats ; Carcinogenicity ; Analytical methods ; Environmental exposure pathway ; Hoechst Celanese(Trademark)
Library Call Number Additional Info Location Last
NTIS  OTS-0000612-0 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 352p
Formaldehyde is a normal metabolite found at low levels in the blood of healthy individuals. It is an essential compound in intermediary metabolism and provides one-carbon units used in the synthesis of many important biomolecules. The purpose of this report is to examine the metabolism and pharmacokinetics of formaldehyde in an attempt to assess whether the intake of formaldehyde from food and environmental sources is likely to result in its accumulation in the body. The steps taken to determine the levels of formaldehyde in food and to subsequently estimate the per capita daily intake of formaldehyde are described. The available literature which describes the metabolism of formaldehyde in animals and man is summarized and pharmacokinetic data are used to assess the effects of ingested and inhaled formaldehyde on the formaldehyde blood and body pools.