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Main Title Comparison of Sister-Chromatid Exchange in Mouse Peripheral Blood Lymphocytes Exposed In vitro and In vivo to Phosphoramide Mustard and 4-Hydroxycyclophosphamide.
Author Bryant, M. F. ; Erexson, G. L. ; Kligerman, A. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Cornell Univ., Ithaca, NY.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/231;
Stock Number PB90-145996
Additional Subjects Lymphocytes ; Cyclophosphamide ; In vitro ; In vivo ; Exposure ; Metabolism ; Kinetics ; Reprints ; Sister chromatid exchange ; Phosphoramide mustards ; Hydroxycyclophosphamide ; Dose-response relationships ; Cell cycle ; Antitumor drug screening assays ; Mutagenicity tests
Library Call Number Additional Info Location Last
NTIS  PB90-145996 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Cyclophosphamide (CO) and two of its known metabolites, 4-hydroxycyclophosphamide (4-OHCP) and phosphoramide mustard (PAM), were analyzed for their ability to induce sister chromatid exchanges (SCEs) in mouse peripheral blood lymphocytes (PBLs) in vitro and in vivo. It is concluded that at equimolar concentrations, CP is a more potent SCE inducer in vivo than PAM and that PAM and 4-OHCP induce equal numbers of SCEs in a dose-dependent manner. The present study also shows that these metabolites of CP are more potent SCE inducers than CP itself in vitro. This relationship might be explained by the differences in pharmacokinetics of these compounds. (Copyright (c) 1989 Elsevier Science Publishers. B.V. (Biomedical Division).)