Record Display for the EPA National Library Catalog


Main Title Teratologic Evaluation of Inhaled Methyl Ethyl Ketone in Rats, prepared by Dow Chemical Company with Cover Letter.
CORP Author Texaco, Inc., Beacon, NY.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 1 Dec 1982
Year Published 1982
Report Number OTS-878210652;
Stock Number OTS-0206178
Additional Subjects Methyl ethyl ketone ; Toxicology ; Evaluation ; Toxicity ; Solvents ; Rats ; Pregnancy ; Inhalation ; Gestation ; Water consumption ; Incidence ; Exposure ; Laboratory tests ; Dow Chemical Company
Library Call Number Additional Info Location Last
NTIS  OTS-0206178 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 43p
Pregnant Sprague-Dawley rats were exposed to 0, 400, 1000 or 3,000 ppm methyl ethyl ketone (MEK) on day 6 through 15 of gestation. Maternal toxicity, as evidenced by decreased weight gain and increased water consumption, was observed among rats exposed to 3,000 ppm MEK. Slight fetotoxicity was observed as evidenced by an increased incidence of some minor skeletal variants among litters from animals exposed to 3,000 ppm MEK. No embryotoxic effects were observed. Although a slight fetotoxic effect and slight maternal toxicity were observed at the highest exposure level, MEK was not embryo-toxic or teratogenic in rats at exposure levels up to 3,000 ppm.