| Main Title |
Effects of pesticides on the immune response / |
| Author |
Dandliker, Walter B.
|
| Other Authors |
|
| CORP Author |
Scripps Clinic and Research Foundation, La Jolla, CA. Dept. of Biochemistry.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Available through the National Technical Information Service. |
| Year Published |
1979 |
| Report Number |
EPA-600/1-79-039; EPA-R-803885 |
| Stock Number |
PB80-130834 |
| OCLC Number |
20957383 |
| Subjects |
Pesticides--Health aspects ;
Pesticides--adverse effects ;
Immune System--drug effects
|
| Additional Subjects |
Pesticides ;
Immunology ;
Ingestion(Biology) ;
Histology ;
Temperature ;
Chlorine organic compound ;
Insecticides ;
Parathion ;
Immune responses ;
Aroclor 1260 ;
Biphenyl/hexachloro ;
Dinoseb ;
Phenol/buty-dinitro ;
PCNB fungicide ;
Benzene/nitro-pentachloro ;
Pyrethrins ;
Resmethrin ;
Butoxide/piperonyl
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-79-039 |
c.1 |
Headquarters Library/Washington,DC |
04/28/2014 |
| EKBD |
EPA-600/1-79-039 |
|
Research Triangle Park Library/RTP, NC |
06/01/2001 |
| ELBD ARCHIVE |
EPA 600-1-79-039 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-79-039 |
|
AWBERC Library/Cincinnati,OH |
06/29/2021 |
| NTIS |
PB80-130834 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
v, 44 pages : illustrations ; 28 cm |
| Abstract |
The influence of various pesticides on the humoral and cellular immune response to fluorescein labeled ovalbumin has been analyzed. Pesticides (Aroclor 1260, Dinoseb, Parathion, pentachloronitrobenzene, piperonyl butoxide, mixed pyrethrins and Resmethrin) were administered intragastrically in corn oil in one dose (one half of LD50) before primary immunization. Control groups included those treated with corn oil alone or immunosuppressed with Methotrexate. Booster immunizations and test bleedings were scheduled at weekly intervals thereafter. The cellular immune response was quantified by redness and swelling, histological examination and by differential temperature measurements of the foot pads after antigen challenge. The concentration, binding affinity and heterogeneity of the serum antibody were determined by fluoroscience polarization measurements. Dinoseb and Parathion depress both the humoral and cellular response. Methotrexate and pentachloronitrobenzene give a late stimulation, while Resmethrin an early, sometimes very marked stimulation of the cellular immune response. Other pesticides showed little or no effect under the conditions tested. Effects on the humoral response were limited to changes in antibody concentration, the binding affinity being nearly constant in all instances. |
| Notes |
"EPA-600/1-79-039." September 1979. |
