Record Display for the EPA National Library Catalog


Main Title Fluoride dose-response analysis for non-cancer effects. [electronic resource] :
CORP Author Environmental Protection Agency, Washington, DC. Office of Water.
Publisher U.S. Environmental Protection Agency, Office of Water, Health and Ecological Criteria Division,
Year Published 2010
Report Number EPA 820-R-10-019
Stock Number PB2011-104363
Subjects Mottled enamel ; Fluorides--Health aspects ; Drinking water--Analysis ; Water--Fluoridation--Health aspects
Additional Subjects Fluorides ; Dosage ; Drinking water ; Dental caries ; Bone ; Brittleness ; Fractures ; Risk assessment ; Therapy ; Preventive medicine
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2011-104363 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 online resource (xv, 144 p.) : digital, PDF file
In response to the 2006 National Research Council (NRC) report: Fluoride in Drinking Water: A Scientific Review of EPA's Standards, the U.S. EPA Office of Water (OW) began a reassessment of the dose-response associated with the effects of ingested fluoride on severe dental fluorosis and bone structure. This report is a culmination of that effort. At low intake levels, fluoride has been shown to have therapeutic value in the prevention of dental caries; however, slightly higher levels, particularly in children during the period of enamel development can lead to dental fluorosis, a condition in which the enamel covering of the teeth fails to crystallize properly. Possible resulting problems include enamel defects ranging from barely discernable markings to brown stains and surface pitting. Prolonged high intake of fluoride, at any age, can result in skeletal fluorosis, a condition which may increase bone brittleness, and in a potential increase in risk of bone fracture. In high-dose cases, severe bone abnormalities can develop, crippling the affected individual.
Title from title screen (viewed on Apr. 18, 2011). "December, 2010". "820-R-10-019". Includes bibliographical references (p. 143-144)