Record Display for the EPA National Library Catalog
RECORD NUMBER: 378 OF 403Main Title | Synthesis of a Novel Fluorinated Benzo(a)pyrene: 4,5-Difluorobenzo(a)pyrene. | |||||||||||
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Author | Agarwal, S. C. ; Lambert, G. ; Padgett, W. ; Nesnow, S. ; | |||||||||||
CORP Author | Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Publisher | c1991 | |||||||||||
Year Published | 1991 | |||||||||||
Report Number | EPA-68-02-4456; EPA/600/J-91/246; | |||||||||||
Stock Number | PB92-110493 | |||||||||||
Additional Subjects | Chemical reactions ; Fluorescent dyes ; Biochemistry ; Benzo(a)pyrene ; Metabolic activation ; DNA damage ; Carcinogens ; Reprints ; Benzo(a)pyrene/difluoro | |||||||||||
Holdings |
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Collation | 6p | |||||||||||
Abstract | The synthesis of 4,5-difluorobenzo(a)pyrene, as a fluorinated probe to investigate the involvement of the K-region in the further metabolic activation of benzo(a)pyrene metabolites, is described. Benzo(a)pyrene-4,5-dione obtained from 2,3-dichloro-5,6-dicyano-1,4-benzoquinone oxidation of cis-4,5-dihydro-4,5-dihydroxybenzo(a)pyrene was fluorinated with dimethylaminosulfur trifluoride to give 4H,5H,4,4,5,5-tetrafluoro-benzo(a)pyrene. Defluorination using lithium aluminum hydride in tetrahydrofuran gave 4,5-difluorobenzo(a)pyrene. |