Record Display for the EPA National Library Catalog


Main Title DNA Alterations (Chapter 3).
Author Shugart, L. ; Bickham, J. ; Jackim, G. ; McMahon, G. ; Ridley, W. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1992
Year Published 1992
Report Number EPA/600/A-93/164 ;ERLN-1087;
Stock Number PB93-221828
Additional Subjects Biological markers ; Organisms ; Exposure ; Toxicity ; Chemical compounds ; Deoxyribonucleic acids ; Mutations ; DNA damage ; Diseases ; Cells(Biology) ; Monitoring ; Chromosomes ; DNA repair ; Abnormalities ; Bioassay ; Reprints ; Oncogenes activation
Library Call Number Additional Info Location Last
NTIS  PB93-221828 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 33p
The exposure of an organism to genotoxic chemicals may induce a cascade of genetic events. Initially, structural alterations to DNA are formed. Next, the DNA damage is processed and subsequently expressed in mutant gene products. Finally, diseases result from the genetic damage. The detection and quantitation of various events in the sequence may be employed as biomarkers of exposure and effects in organisms exposed to genotoxic agents in the environment. The methods to monitor exposure to genotoxic chemicals are based upon either: (1) direct measurement of DNA structural change; (2) the detection of their consequences by measuring DNA repair directly or indirectly; or (3) the production of mutations in the genome of the exposed organisms. Adducts are a type of structural change involving covalent attachments of a chemical or its metabolite to DNA. Several analytical procedures are currently used to monitor the formation of DNA adducts directly. (Copyright (c) 1992 by Lewis Publishers.)