| Main Title |
Structure-Activity Relationships for Osteolathyrism. 1. Effects of Altering the Semicarbazide Structure. |
| Author |
Schultz, T. W. ;
Ranney, T. S. ;
Riggin, G. W. ;
Cajina-Quezada, M. ;
|
| CORP Author |
Tennessee Univ., Knoxville.;Environmental Research Lab.-Duluth, MN. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA-R-813158; EPA/600/J-88/454; |
| Stock Number |
PB90-147372 |
| Additional Subjects |
Toxicology ;
Connective tissue ;
Mutagens ;
Frogs ;
Embryos ;
Exposure ;
In vitro analysis ;
Reprints ;
Osteolathyrism ;
Semicarbazides ;
Xenopus laevis ;
Teratogens ;
Structure-activity relationship
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-147372 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
The toxic and osteolathyrogenic effects of 15 chemicals reflecting modifications of semicarbazide (H2N-N(H)-C(=O)-NH2) were evaluated using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX). Osteolathyrism, the failure of connective tissue fibers to cross-link correctly, is expressed as gross alterations in the long axis of the embryo and a sinusoidal configuration of the notochord. Alteration (addition or subtraction) at the hydrazino (H2NNH-) end of the molecule sharply reduces osteolathyrogenic activity. Alteration at the amino (H2N-) end of the molecule results in a graded response. The replacement of oxygen with sulfur causes no loss of osteolathyrogenic activity. (Copyright (c) 1988 by the American Microscopical Society, Inc.) |
