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Main Title Structure-Activity Relationships for Osteolathyrism. 1. Effects of Altering the Semicarbazide Structure.
Author Schultz, T. W. ; Ranney, T. S. ; Riggin, G. W. ; Cajina-Quezada, M. ;
CORP Author Tennessee Univ., Knoxville.;Environmental Research Lab.-Duluth, MN.
Publisher c1988
Year Published 1988
Report Number EPA-R-813158; EPA/600/J-88/454;
Stock Number PB90-147372
Additional Subjects Toxicology ; Connective tissue ; Mutagens ; Frogs ; Embryos ; Exposure ; In vitro analysis ; Reprints ; Osteolathyrism ; Semicarbazides ; Xenopus laevis ; Teratogens ; Structure-activity relationship
Library Call Number Additional Info Location Last
NTIS  PB90-147372 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The toxic and osteolathyrogenic effects of 15 chemicals reflecting modifications of semicarbazide (H2N-N(H)-C(=O)-NH2) were evaluated using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX). Osteolathyrism, the failure of connective tissue fibers to cross-link correctly, is expressed as gross alterations in the long axis of the embryo and a sinusoidal configuration of the notochord. Alteration (addition or subtraction) at the hydrazino (H2NNH-) end of the molecule sharply reduces osteolathyrogenic activity. Alteration at the amino (H2N-) end of the molecule results in a graded response. The replacement of oxygen with sulfur causes no loss of osteolathyrogenic activity. (Copyright (c) 1988 by the American Microscopical Society, Inc.)