Record Display for the EPA National Library Catalog


Main Title Biological Variability and the Influence of Stress on Cholinesterase Activity.
Author Rattner, B. A. ; Fairbrother., A. ;
CORP Author Patuxent Wildlife Research Center, Laurel, MD.;Corvallis Environmental Research Lab., OR.
Publisher 1990
Year Published 1990
Report Number EPA/600/D-90/072;
Stock Number PB90-246307
Additional Subjects Stress(Physiology) ; Cholinesterase ; Metabolism ; Vertebrates ; Toxicology ; Blood proteins ; Cholinesterase inhibitors ; Pesticides ; Reproduction(Biology) ; Circadian rhythms ; Genetics ; Carbamates ; Reprints ; Brain chemistry ; Biological markers ; Organophosphorus insecticides ; Species specificity
Library Call Number Additional Info Location Last
NTIS  PB90-246307 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 34p
Normal activity of brain and plasma cholinesterase in higher vertebrates is known to be affected by age, genetics, circadian rhythms, sex, endocrine function, and reproductive status. Various stressors (e.g., nutritional plane, ambient temperature, disease) have also been demonstrated to alter cholinesterase activity in birds and mammals. Naturally-occurring and stress-induced variation in cholinesterase activity should be considered when the biomarker is used to assess exposure to organophosphorus and carbamate pesticides. In addition to pesticide metabolism (activation and detoxication) and physiological condition, basal cholinesterase activity may also be a determinant of sensitivity to cholinesterase-inhibiting pesticides. The present review examines the biological and stress-induced sources of variability in brain and blood cholinesterase activity of non-exposed vertebrates, and the toxicological and hazard assessment ramifications of such variability.