| Main Title |
Toxicological review of chloral hydrate (CAS No. 302-17-0) in support of summary information on the integrated risk information system (IRIS) / {electronic resource} : |
| Author |
Benson, Robert.
|
| Other Authors |
|
| CORP Author |
Environmental Protection Agency, Washington, DC. |
| Publisher |
U.S. Environmental Protection Agency, |
| Year Published |
2000 |
| Report Number |
EPA/635/R-00/006 |
| Stock Number |
PB2001-100094 |
| OCLC Number |
53840423 |
| Subjects |
Chloral Hydrate--toxicity ;
Dose-Response Relationship, Drug ;
Risk Assessment
|
| Additional Subjects |
Toxicity ;
Chloral hydrate ;
Environmental exposure ;
Health hazards ;
Dose-response relationships ;
Hazardous substances ;
Carcinogens ;
Chemical properties ;
Physical properties ;
Dermal absorption ;
Carcinogenicity tests ;
Toxicology ;
Inhalation ;
Oral dosage ;
Dose rate ;
Epidemiology ;
Bioassay ;
Chronic disease ;
Chronic exposure ;
Reproduction(Biology) ;
Factor analysis ;
CAS No 302-17-0 ;
IRIS(Integrated Risk Information System) ;
Taxicokinetics
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJAI |
EPA 635/R-00-006 |
Internet only |
Region 3 Library/Philadelphia, PA |
07/27/2007 |
| NTIS |
PB2001-100094 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
70 pages ; 28 cm |
| Abstract |
This document presents background and justification for the hazard and dose-response assessment summaries in EPA's Integrated Risk Information System (IRIS). IRIS summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC), and a carcinogenicity assessment. The RfD and RfC provide quantitative information for noncancer dose-response assessments. The RfD is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis but may not exist for other toxic effects such as some carcinogenic responses. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious noncancer effects during a lifetime. The inhalation RfC is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). It is generally expressed in units of mg/m 3. |
| Notes |
Title from title screen (viewed Nov. 24, 2003). Author, Robert Benson. "August 2000." "EPA/635/R-00/006." Includes bibliographical references. |
| Contents Notes |
This document presents background and justification for the hazard and dose-response assessment summaries in EPA's Integrated Risk Information System (IRIS). IRIS summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC), and a carcinogenicity assessment. |
