Record Display for the EPA National Library Catalog


Main Title Effects of Selected Organic Drinking Water Contaminants on Male Reproduction.
Author Borzelleca, Joseph F. ; Carchman, Richard A. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.
Year Published 1982
Report Number EPA-R-804290; EPA-600/1-82-009;
Stock Number PB82-259847
Additional Subjects Reproduction(Biology) ; Potable water ; Toxicology ; Bioassay ; Rats ; Laboratory animals ; Chlorine organic compounds ; Water pollution effects(Animals) ; Drinking water ; Cell lines ; Kepone ; Benzene/hexachloro ; Toluene/dinitro ; Butane/tetrabromo ; Ethylene/trichloro ; Ethylene/dichloro ; Ethane/dichloro ; Chloral hydrate ; Methane/trichloro ; Ethane/trichloro ; Methane/chloro-dibromo
Library Call Number Additional Info Location Last
NTIS  PB82-259847 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 149p
Because of the recent increase in exposure of individuals to potentially harmful chemicals, it has become increasingly important to test the potential of environmental chemicals to cause adverse reproductive effects. The Division of Toxicology within the Department of Pharmacology, Medical College of Virginia has responded to this need by examining the abilities of Kepone, hexachlorobenzene, 2,4-dinitrotoluene, 1,2,3,4-tetrabromobutane, chloral hydrate, 1,1,2-trichloroethylene, 1,2-dichloroethylene, 1,2-dichloroethane, dibromochloromethane, trichloromethane, and 1,1,1-trichloroethane to elicit harmful reproductive effects. The following tests were used to assess the extent of these effects: analysis of effects upon rat ejaculate volume and sperm morphology, distribution studies in rats, determination of the cellular sites of action in a P388D1 lymphoid neoplasm cell line, performance of a multi-generation murine experiment which included dominant lethal and teratologic studies, and analysis of the inhibition of mouse testicular DNA synthesis.