Stream pollution investigations of the North Platte River Basin, intended to supply an interpretation of currently available data for use by the Bureau of Reclamation in preparation of a comprehensive basin report, are reviewed. Included is a detailed survey of the North Platte River between Casper, Wyoming, and Guernsey Reservoir where the extent, types, and major sources of pollution have been determined. Pollution sources include oil refineries, municipal sanitary sewage, and beet sugar refineries. Recommendations regarding minimum stream flows in this stretch of the stream are described, along with estimates of possible benefits from increased flows.