| Main Title |
Summary of the EPA workshop on carcinogenesis bioassay via the dermal route : April 28-29, 1987, Washington, D.C. / |
| CORP Author |
Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Reproduced by U.S. Dept. of Commerce, National Technical Information Service, |
| Year Published |
1987 |
| Report Number |
EPA 560/6-89-002; EPA-68-01-7266 |
| Stock Number |
PB90-146309 |
| OCLC Number |
25057402 |
| Subjects |
Skin absportion--Physiological aspects--Congresses ;
Carcinogenesis--Congresses
|
| Additional Subjects |
Meetings ;
Skin(Anatomy) ;
Toxicity ;
Acrylates ;
Bioassay ;
Methacrylates ;
Laboratory animals ;
Carcinogenicity tests ;
Environmental exposure pathways ;
Chemical effluents ;
Pharmacokinetics ;
Dose-response relationships
|
| Internet Access |
|
| Local Library Info |
| Library |
Local Subject |
Local Note |
| EKB |
|
Library copy is an earlier, typescript version with no publication information. |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJED |
EPA-560/6-89-002 |
|
OCSPP Chemical Library/Washington,DC |
01/10/1992 |
| EKBD |
EPA 560/6-89-002 |
|
Research Triangle Park Library/RTP, NC |
08/04/2014 |
| NTIS |
PB90-146309 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8 leaves |
| Abstract |
Traditionally, the oral route has been the most common route of administration in bioassays which tested the potential carcinogenicity of chemicals. Regulatory agencies, however, prefer to have test chemicals applied by the same route as expected human exposure, whenever possible. Since human exposure to industrial chemicals is frequently via the dermal route, this has become a route of choice for animal testing of certain chemicals. However, protocol design for dermal bioassays presents many unique problems which must be addressed before guidelines for bioassays by the dermal route can be formulated. Furthermore, it may be feasible to develop a limited dermal protocol to screen certain classes of chemicals such as acrylates/methacrylates. Recognizing the need for this workshop, it was designed in two distinct parts; to address the problems inherent in the development of a generic protocol for dermal bioassays and, a specific limited dermal bioassay protocol for acrylates/methacrylates. |
| Notes |
Includes bibliographical references. "EPA 560/6-89-002." Sponsored by the Office of Toxic Substances, U.S. Environmental Protection Agency. |
