||Effects of nitrogen dioxide on pulmonary function in human subjects : an environmental chamber study /
Kerr, H. David. ;
Kulle, Thomas J. ;
McIlhany, Mary Lou ;
||Maryland Univ. at Baltimore. Div. of Pulmonary Diseases. ;Johns Hopkins Univ., Baltimore, Md. Dept. of Environmental Health Sciences.;Health Effects Research Lab., Research Triangle Park, N.C.
|| U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Nitrogen dioxide--Toxicology. ;
Respiratory system ;
Nitrogen dioxide ;
Experimental data ;
Nitrogen inorganic compounds ;
Signs and symptoms ;
Respiratory diseases ;
Air pollution ;
Body weight ;
Environmental health ;
Air pollution effects(Humans) ;
Toxic substances ;
Pulmonary function ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||vii, 21 pages ; 28 cm.
Twenty human subjects with asthma and chronic bronchitis and ten normal, healthy adults were exposed to 0.5 ppm of nitrogen dioxide (NO2) for two hours in an environmental chamber. They engaged in one 15-minute, light to medium-exercise stint on a bicycle ergometer during this period. The subjects with asthma experienced the greatest symptoms with exposure to NO2, i.e., seven of thirteen noting slight burning of the eyes, slight headache, and chest tightness or labored breathing with exercise. One each of the subjects with chronic bronchitis and the healthy, normal group experienced slight nasal discharge. Significant changes from control values for the group as a whole with exposure to NO2 were observed for the following pulmonary function tests: quasi-state compliance for the twenty subjects with asthma and chronic bronchitis as well as for the ten normal subjects, and functional residual capacity for the twenty subjects with asthma and chronic bronchitis. Subjects with asthma and chronic bronchitis as separate groups (n = 13 and 7 respectively) did not show any significant changes in pulmonary function with the NO2 exposure, even though the group of thirteen subjects with asthma experienced with greatest symptoms.
"EPA 600/1-78/025." Includes bibliographical references (pages 17-21). Microfiche.