Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 6
|Main Title||7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid).|
|Author||Joyce, N. J. ; Daniel, F. B. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Carcinogens ; Deoxyribonucleic acids ; Rats ; Liver ; Deoxyribonucleic acids ; Parenteral infusions ; Chemical analysis ; Fluorescence ; Aromatic polycyclic hydrocarbons ; Malignant neoplasms ; Reprints ; Benzanthracene/dimethyl ; Benzanthracene/hydroxymethyl-dimethyl ; High performance liquid chromatography ; Cancer|
The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide.