Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Changes in Testicular and Serum Hormone Concentratios in the Male Rat Following Treatment with 'm'-Dinitrobenzene (Journal Version).
Author Rehnberg, G. L. ; Linder, R. E. ; Goldman, J. M. ; Hein, J. F. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/203;
Stock Number PB89-144455
Additional Subjects Toxicity ; Hormones ; Testes ; Blood serum ; Gonadotropins ; Hypothalamus ; Nitroaryl compounds ; Pituitary gland ; Atrophy ; Rats ; Testosterone ; Reproductive system ; Reprints ; Dinitrobenzenes ; Biological effects ; Epithelium
Library Call Number Additional Info Location Last
NTIS  PB89-144455 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/08/1989
Collation 12p
m-Dinitrobenzene (m-DNB)-induced testicular atrophy has been attributed to a direct effect upon the germinal epithelium. However, such degenerative changes in the germinal epithelium should induce shifts in the testicular hormonal milieu, which would in turn alter the hypothalmic-pituitary gonadal axis in general. The study evaluated the endocrine status of male rats following a single oral dose of m-DNB (32 mg m-DNB/kg). Serum and pituitary leuteinizing hormone, follicle-stimulating hormone (FSH), and protactin and hypothalamic gonadotropin-releasing hormone (GnRH) concentrations were determined. Testosterone and androgen-binding protein concentrations in serum, interstitial fluid, seminiferous tubule fluid, and caput epididymis were also determined. In vitro basal and hCG-stimulated testosterone release was determined in the decapsulated testis. These data demonstrate that m-DNB exerts a direct effect on the testes and not through alterations in hypothalamic and pituitary control of gonadal function. (Copyright (c) 1988 Academic Press, Inc.)