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Main Title Carcinogenic effects of arsenic compounds in drinking water /
Author Shirachi, Donald Y. ; Tu, S. H. ; McGowan, J. P.
Other Authors
Author Title of a Work
Tu, Shing-Hui.
McGowan, John P.
CORP Author University of the Pacific, Stockton, CA.;Health Effects Research Lab., Cincinnati, OH.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1987
Report Number EPA/600/1-87/007; EPA-R-811619
Stock Number PB87-232542
Subjects Drinking water--United States--Analysis ; Arsenic compounds ; Drinking water--Analysis
Additional Subjects Arsenic ; Carcinogens ; Water pollution ; Rats ; Concentration(Composition) ; Liver ; Dosage ; Arsenates ; Drinking water
Library Call Number Additional Info Location Last
NTIS  PB87-232542 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 60 pages ; 28 cm
The primary objective of the research project was to determine whether there was a dose-response effect of arsenite (AsIII) as a promoter of DENA-initiated tumors in the kidneys of partially hepatectomized rats. Secondary objectives were to complete the study extending from the previous grant which was to determine whether arsenite (AsIII), arsenate (AsV) and dimethylarsinic acid (DMA) were initiator carcinogens and/or promoters of DENA-initiated tumors in the rat kidney. In addition an analytical method for measuring the above three arsenic species simultaneously in the same biological sample was to be developed. A dose-response was observed for AsIII promotion in partially hepatectomized DENA-initiated rats at concentrations of 40, 80 and 160 mg/L in the drinking water but it was not statistically significant. AsIII and AsV did not have any initiator activity in intact male Wistar rats but significantly promoted DENA-initiated renal tumors in these animals. DMA had neither initiator nor promoter activity.
Caption title. "August 1987." Includes bibliographical references. "EPA/600/1-87/007." Microfiche.