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Main Title Morphological Transformation and Chromosome Damage by Amsacrine in C3H/10T(1/2) Clone 8 Cells.
Author Ferguson, L. R. ; Van Zijl, P. ; Nesnow, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Auckland Univ. (New Zealand).
Year Published 1986
Report Number EPA/600/J-86/375;
Stock Number PB87-203147
Additional Subjects Morphology ; Cells(Biology) ; Chemotherapy ; Carcinogens ; Drug therapy ; Mutations ; Reprints ; Amsacrine(4'-(9-acridinylamino)methanesulfon-m-anisidide) ; Chromosome abnormalities ; Cell survival
Library Call Number Additional Info Location Last
NTIS  PB87-203147 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Morphological transformation, cell survival, chromosomal aberrations and micronuclei were measured in C3H/101/2CL8 cells after 24 hour exposure to amsacrine. A weak but dose-related increase in the percentage of dishes containing transformed foci occurred. As previously reported for alkylating agents, this effect was increased by treating 5 days instead of 1 day after plating. There was no evidence for gene mutation at the Na/K ATPase locus, although amsacrine induced micronuclei in a large percentage of cells and chromosomal aberrations, including interchange events and double minute chromosomes, in dividing cells. It would appear that transformation and chromosomal events may be related in amsacrine treated C3H/10T1/2CL8 cells. The results strongly suggest that amsacrine has carcinogenic potential, possibly related to its chromosome-breaking properties. (Copyright (C) 1986 Elsevier Science Publishers B.V.)