Record Display for the EPA National Library Catalog


Main Title Acute Toxicity Studies in Rats and Rabbits with Cover Letter.
CORP Author International Research and Development Corp., Mattawan, MI. ;Olin Corp., New Haven, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 24 Nov 1982
Year Published 1982
Report Number 878210870;
Stock Number OTS-0205877
Additional Subjects Toxicity ; Laboratory animals ; Alkylating agents ; Oral dosage ; Rats ; Rabbits ; Dermal absorption ; Eye ; Irritation ; Response(Biology) ; Mortality ; Chemical compounds ; Body weight ; Alkyl epoxides ; Oilin Corporation
Library Call Number Additional Info Location Last
NTIS  OTS-0205877 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 88p
The acute oral LD50 of Olin-35836 in the albino rat was found to be 3160 mg. /kg. Confidence could not be calculated because of the all-or-none response exhibited by the groups of rats administered the test material. Olin-53836 did not produce any evidence of dermal irritation or toxicity in the rabbits to which the test material was applied in dosages as high as 2000 mg. /kg. Instillation of Olin-53836 into the unwashed eyes of albino rabbits produced severe irritation including purulent discharge, pannus and opacity of the cornea. These signs were still in evidence at the end of 7 days of observation. However, those rabbits in which the eyes were irrigated 2 and 4 seconds after instillation of the test material, only slight irritation to the conjunctivae was noted which disappeared within 4 days after treatment.