Record Display for the EPA National Library Catalog


Main Title Teratology and acute toxicology of selected chemical pesticides administered by inhalation /
Author Newell, Gordon W.
Other Authors
Author Title of a Work
Dilley, James V.
Publisher U.S. Environmental Protection Agency Health Effects Research Laboratory,
Year Published 1978
Report Number EPA 600/1-78-003; PB 277 077; EPA-68-02-1751
Stock Number PB-277 077
OCLC Number 20440544
Subjects Pesticides--Toxicology ; Teratogenic agents
Additional Subjects Toxicology ; Congenital abnormalities ; Pesticides ; Insecticides ; Aerosol generators ; Aerosols ; Concentration(Composition) ; Test chambers ; Exposure ; Rats ; Bioassay ; Laboratory animals ; Females ; Males ; Lethal dosage ; Pregnancy ; Embryology ; Ingestion(Biology) ; Cholinesterase ; Toxicity ; Pathology ; Experimental data ; Teratology ; Inhalation ; Fetuses ; Parathion ; Intravenous injections ; Topical administration ; Azinphosmethyl ; Phorate
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-78-003 Headquarters Library/Washington,DC 05/16/2014
EKBD  EPA-600/1-78-003 Research Triangle Park Library/RTP, NC 06/13/2003
ELBD ARCHIVE EPA 600-1-78-003 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-78-003 AWBERC Library/Cincinnati,OH 11/22/2022
NTIS  PB-277 077 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xii, 49 pages : tables ; 28 cm
A method was developed for generating pesticide aerosols within the respirable particle size range of 0.3 to 3.0 micrometers. Analytical methods were established for determining pesticide concentrations in chamber air samples and in tissues. A unique chamber exposure system was developed that permitted the simultaneous exposure of four different groups of rats to four different concentrations of pesticide from a single generation source. Parathion, methyl parathion, Thimet, Guthion, and Azodrin were administered to rats by the oral, dermal, intravenous or inhalation routes, and the LD50s or LC50s were compared. Inhalation was the most toxic route of administration, followed by the intravenous, oral, and then dermal routes. Females were more sensitive than males to parathion and Thimet by all routes of administration. Azodrin was more toxic to females by the intravenous and oral routes, and Guthion was more toxic to females by dermal application. No correlation was found between mortality and cholinesterase inhibition or blood or liver pesticide content. No gross or histopathological lesions were identified that could be attributed to pesticide treatment. Timed-pregnant rats were exposed to vapors/aerosols of chloroform, ethylene thiourea, Thimet, Bromacil, and Simazine for 1 to 3 hours daily on days 7 through 14 of gestation. No dose-related terata were found in any of the studies.
"EPA 600/1-78-003." "PB 277 077." "Contract no. 68-02-1751." "January 1978."