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Main Title Letter from Eastman Kodak Company to US EPA regarding Information on 5-Methyl-2-Octanone 90-Day Feeding Study.
CORP Author Tennessee Eastman Co., Kingsport.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 21 Feb 1979
Year Published 1979
Report Number 8EHQ-0279-0275;
Stock Number OTS-0200457
Additional Subjects Toxicity ; Solvents ; Rats ; Gavage ; Laboratory tests ; Central nervous system ; Neuropathy ; Dosage ; Feeding ; US EPA ; Alkanes ; Ketones ; In vivo analysis ; Neurotoxins ; Metabolism ; Adverse effects ; MHK solvent ; 5-methyl-2-octanone ; Eastman Kodak Company
Holdings
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Status
NTIS  OTS-0200457 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract
The submission reports that chronic administration of MHK Solvent (5-methyl-2-octanone; 72% minimum) to rats by gavage over a 90-day period induced signs of hind-limb weakness in several of the test animals. Histologic examination of peripheral and central nervous system sections revealed giant axonal neuropathy in the MHK Solvent-dosed rats.