Main Title |
Effect of Methyl Oleate Hydroperoxide, a Possible Toxic Ozone Intermediate, on Human Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Erythrocytes. |
Author |
Williams, P. ;
Calabrese, E. J. ;
Moore, G. S. ;
|
CORP Author |
Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-R-805797; EPA/600/J-83/276; |
Stock Number |
PB85-173177 |
Additional Subjects |
Ozone ;
Oxidation ;
Toxicology ;
Blood cells ;
Erythrocytes ;
Humans ;
Sensitivity ;
Reprints ;
Dehydrogenase/glucose-phosphate ;
Oleic acid/hydroperoxyl-methyl ;
Glutathiones
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-173177 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Erythrocytes of both normal and glucose 6-phosphate dehydrogenase (G-6-PD)-deficient humans responded in a dose-dependent manner to the oxidant stress of methyl oleate hydroperoxide (MOHP) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in reduced glutathione (GSH). The G-6-PD-deficient erythrocytes displayed a markedly enhanced sensitivity to MOHP-induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels. |