Record Display for the EPA National Library Catalog


Main Title Effect of the Age of B6C3F1 Mice on Phenobarbital Promotion of Diethylnitrosamine Initiated Liver Tumors.
Author Klaunig, J. E. ; Weghorst, C. M. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo. Dept. of Pathology.
Year Published 1987
Report Number EPA/600/J-87/276;
Stock Number PB88-185533
Additional Subjects Liver neoplasms ; Nitroso compounds ; Phenobarbital ; Carcinogens ; Mice ; Aging(Biology) ; Adenoma ; Reprints ; Diethylnitrosamine ; Cocarcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB88-185533 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Chronic exposure to phenobarbital (PB) in the drinking water of male B6C3F1 mice starting at 4 weeks of age and subsequent to a single (ip) injection of diethylnitrosamine (DENA) administered on Day 15 of age has been shown to result in the inhibition of hepatic tumor formation. In the study, the authors varied the time of onset of PB administration to determine if sexual maturity would affect liver tumor formation and progression. Data from the study suggest that the inhibition of hepatocellular tumorigenesis by PB remains intact even when the start of the administration of PB is withheld up to 12 weeks of age. (Copyright (c) 1987 Academic Press, Inc.)