Record Display for the EPA National Library CatalogRECORD NUMBER: 27 OF 28
|Main Title||Utilization of the Rabbit Alveolar Macrophage and Chinese Hamster Ovary Cell for Evaluation of the Toxicity of Particulate Materials. 1. Model Compounds and Metal-Coated Fly Ash.|
|Author||Garrett, Neil E. ; Campbell, James A. ; Stack, H. Frank ; Waters, Michael D. ; Lewtas, Joellen ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Fly ash ; Air pollution ; Cell cultures ; In vitro analysis ; Reprints ; Particulates|
Data are presented which detail the effects of model particulate compounds and fly ash particles on rabbit alveolar macrophage (RAM) and Chinese hamster ovary (CHO) cells. Silica, silicic acid, titanium dioxide, and size-fractionated (0,-2, 2-5, and 5-8 um) fly ash particles with and without coatings of nickel, lead, or cadmium oxides were the experimental particles. Silica was the most toxic particle studied. Cell viability and ATP in the RAM assay and colony survival in the CHO assay showed an almost identical response to silica and silicic acid.