Record Display for the EPA National Library Catalog


Main Title Utilization of the Rabbit Alveolar Macrophage and Chinese Hamster Ovary Cell for Evaluation of the Toxicity of Particulate Materials. 1. Model Compounds and Metal-Coated Fly Ash.
Author Garrett, Neil E. ; Campbell, James A. ; Stack, H. Frank ; Waters, Michael D. ; Lewtas, Joellen ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-098;
Stock Number PB83-210294
Additional Subjects Toxicology ; Fly ash ; Air pollution ; Cell cultures ; In vitro analysis ; Reprints ; Particulates
Library Call Number Additional Info Location Last
NTIS  PB83-210294 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 23p
Data are presented which detail the effects of model particulate compounds and fly ash particles on rabbit alveolar macrophage (RAM) and Chinese hamster ovary (CHO) cells. Silica, silicic acid, titanium dioxide, and size-fractionated (0,-2, 2-5, and 5-8 um) fly ash particles with and without coatings of nickel, lead, or cadmium oxides were the experimental particles. Silica was the most toxic particle studied. Cell viability and ATP in the RAM assay and colony survival in the CHO assay showed an almost identical response to silica and silicic acid.