Record Display for the EPA National Library Catalog


Main Title Absence of Mutagenicity in the Urine of Autopsy Service Workers Exposed to Formaldehyde: Factors Influencing Mutagenicity Testing of Urine.
Author Connor, T. H. ; Ward, J. B. ; Legator, M. S. ;
CORP Author Texas Univ. Medical Branch at Galveston.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-807548; EPA/600/J-85/403;
Stock Number PB86-204641
Additional Subjects Industrial medicine ; Histidine ; Reprints ; Formaldehyde ; Occupational safety and health ; Mutagenesis ; Urinalysis ; Autopsies
Library Call Number Additional Info Location Last
NTIS  PB86-204641 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The study examined the effect of exposure to autopsy workers to formaldehyde using urinary mutagenicity testing with Salmonella typhimurium. A matched control group was also studied. Additional studies including the recovery of histidine from urine samples, the determination of histidine in urine samples and the effect of exogenous and urinary histidine on the mutagenicity assay were also carried out. Results showed that there was no increase in mutagenicity in the autopsy workers as compared to the control group. A large proportion of the exposed individuals had toxic urine while only two of the control group has similar toxic urine. However, the toxic material in the urine samples has been isolated and does not appear to be related to the formaldehyde exposure. In conclusion, exogenous histidine and certain growth factors present in human urine can affect the outcome of both plate incorporation and fructuation assays for mutagenicity and care must be taken when interpreting results of this type of mutagenicity studies.