Record Display for the EPA National Library Catalog


Main Title Kepone-Induced Scoliosis and Its Histological Consequences in Fish.
Author Couch, John ; Winstead, James ; Goodman., Larry ;
CORP Author Environmental Research Lab., Gulf Breeze, Fla.
Year Published 1977
Report Number EPA/600/J-77/077;
Stock Number PB-277 182
Additional Subjects Fishes ; Scoliosis ; Insecticides ; Pesticides ; Toxicology ; Toxic diseases ; Chlorine organic compounds ; Minnows ; Nervous system ; Pathology ; Musculosketal disorders ; Central nervous system ; Histology ; Aquatic animals ; Experimental data ; Reprints ; Kepone ; Laboratory tests
Library Call Number Additional Info Location Last
NTIS  PB-277 182 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.