Record Display for the EPA National Library Catalog


Main Title Mechanisms of carcinogenesis in risk identification
Other Authors
Author Title of a Work
Vainio, H.
Publisher International Agency for Research on Cancer ;
Year Published 1992
OCLC Number 29225008
ISBN 9283221168
Subjects Carcinogenesis ; Carcinogenicity testing ; Carcinogenicity Tests ; Carcinogens ; Neoplasms--etiology ; Neoplasms--genetics
Library Call Number Additional Info Location Last
EKBD  IARC/SP-116 Research Triangle Park Library/RTP, NC 09/01/1995
Collation xiv, 615 p. : ill. ; 25 cm.
Includes bibliographical references and indexes.
Contents Notes
Critical molecular targets in chemical carcinogenesis -- Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis / J.L. Bos and C.F. van Kreijl -- Tumour suppressor genes, multistage carcinogenesis and molecular epidemiology / C.C. Harris -- Receptor-mediated carcinogenesis / G.W. Lucier -- Mechanisms of carcinogenicity -- Mechanisms of action of known human carcinogens / J.C. Barrett -- Use of short-term tests in determining the genotoxicity or nongenotoxicity of chemicals / J. Ashby -- Performance of tests for cell transformation and gap-junction intercellular communication for detecting nongenotoxic carcinogenic activity / S.H.H. Swierenga and H. Yamasaki -- Genotoxic and nongenotoxic carcinogens: mechanisms of action and testing strategies / C. Ramel -- Use of 32P-postlabelling to distinguish between genotoxic and nongenotoxic carcinogens / D.H. Phillips -- Peroxisome proliferation and hepatocarcinogenesis / J.K. Reddy and M.S. Rao -- Immunosuppression and cancer / L.J. Kinlen. (cont) Sex hormones and cancer / T.J.A. Key and V. Beral -- Structure-activity relationships for carcinogens with different modes of action / H.S. Rosenkranz -- Chemically induced cell proliferation in carcinogenesis / B.E. Butterworth ... {et al.} -- Role of DNA repair in carcinogenesis / B.W. Stewart -- Animal carcinogenicity tests and their interpretation -- Chemicals classified by IARC: their potency in tests for carcinogenicity in rodents and their genotoxicity and acute toxicity / D.B. McGregor -- Medium-term bioassays for carcinogens / N. Ito, T. Shirai and R. Hasegawa -- Predictive value of hepatic preneoplastic lesions as indicators of carcinogenic response / P. Bannasch and H. Zerban -- Transgenic mice in carcinogenicity testing / R. Griesemer and R. Tennant -- Chemical toxicity and chemical carcinogenesis. Is there a causal connection? A comparative morphological evaluation of 1500 experiments / J.E. Huff -- Species-specific mechanisms of carcinogenesis / J.A. Swenberg ... {et al.}. (cont) Species differences in carcinogen metabolism and interspecies extrapolation / E. Dybing and H.S. Huitfeldt -- Biological markers in exposed humans -- Significance of DNA and protein adducts / K. Hemminki -- Biological markers in exposed humans: gene mutation / B. Lambert -- Human cytogenetic damage as a predictor of cancer risk / M. Sorsa, J. Wilbourn and H. Vainio -- Data analysis and modelling -- Considerations in the conduct of meta-analysis using data from animal carcinogenicity experiments / B. McKnight -- Meta-analysis of epidemiological studies of carcinogenesis / J. Peto -- Dose-response relationships in carcinogenesis / D. Krewski, M.J. Goddard and J.M. Zielinski -- Role of epidemiological observation in elucidating the mechanisms of carcinogenesis / J. Kaldor.