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RECORD NUMBER: 5 OF 24

OLS Field Name OLS Field Data
Main Title Comparison of Lung Antioxidant Levels in Humans and Laboratory Animals.
Author Slade, R. ; Stead, A. G. ; Graham, J. A. ; Hatch, G. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/309;
Stock Number PB86-162377
Additional Subjects Antioxidants ; Toxicity ; Humans ; Laboratory animals ; Respiratory system ; Reprints ; Ascorbic acid ; Sulfhydryls ; Tocopherol
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-162377 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract
Basal lung concentrations of ascorbic acid (AA), nonprotein sulfhydryls (NPSH), and a-tocopherol (a-T) were determined in rabbits, guinea pigs, rats, hamsters, mice, domestic pigs and sheep, and in human lung samples obtained from cancer surgery patients. Significant differences were found among the laboratory animals: AA levels ranged from 25.6 mg% (mg/100 g wet wt) in hamsters to 41.7 mg% in mice, NPSH from 50.9 mg% in rats to 84.7 mg% in rabbits, and a-T from 1.01 mg% in hamsters to 2.74 mg% in rats. Porcine lung AA and NPSH approximated those of the laboratory animals and their a-T levels were the highest of all species studied. Sheep lung AA levels were comparable to the other species, although their NPSH and a-T levels appeared to be lower. Human lung concentrations of NPSH (5.2 mg%) and a-T (0.85 mg%) appeared low, and the mean AA concentration (22.1 mg%) was similar to those of laboratory animals.