Record Display for the EPA National Library Catalog


Main Title Use of Genetic Activity Profiles in Hazard Evaluation.
Author Waters, M. D. ; Stack, H. F. ; Brady, A. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher Nov 88
Year Published 1988
Report Number EPA/600/D-88/246;
Stock Number PB89-129415
Additional Subjects Profiles ; Hazardous materials ; Mutagenicity tests ; Toxicity ; Carcinogens ; Mutagens ; Laboratory animals ; Concentration(Composition) ; Health effects ; Dibromochloropropane ; Risk assessment ; Propane/dibromo-chloro
Library Call Number Additional Info Location Last
NTIS  PB89-129415 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 23p
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants for purposes of hazard/risk assessment. Dose information is collected from the open literature: either the lowest effective dose or the highest ineffective dose tested is recorded for each agent and bioassay system. For each agent in the data base, the quantitative results from genetic and related test systems are represented by computer-generated bar graphs 'genetic activity profiles.' Bioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. Genetic activity profiles were prepared 187 chemicals, e.g., dibromochloropropane, for the use of the International Agency for Research on Cancer (IARC) Working Group.