Record Display for the EPA National Library Catalog


Main Title Evaluation of Sensory System Function Using Reflex Modification of the Startle Response.
Author Crofton, K. M. ; Sheets., L. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/445;
Stock Number PB91-109371
Additional Subjects Public health ; Chemical compounds ; Environmental surveys ; Senses ; Exposure ; Toxicology ; Reflexes ; Nervous system disorders ; Reprints ; Toxic substances ; Startle raction
Library Call Number Additional Info Location Last
NTIS  PB91-109371 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Methods to measure damage to sensory systems following toxicant exposure vary from rapid and subjective tests (e.g., pinna reflex) to time-consuming and objective tests (e.g., psychophysical tests). Reflex modification of the startle response represents an alternative technique in the assessment of sensory function. Advantages of this procedure include: no prior training requirements, rapid and objective measurement of sensory thresholds, ability to differentiate sensory from non-sensory damage, and potential for predictive validity. This procedure has also been shown to be sensitive to a variety of neurotoxic compounds. Future research should concentrate on demonstrating the research potential of this technique for use in neurotoxicology.