Record Display for the EPA National Library Catalog


Main Title Mouse Skin Tumor-Initiating Activity of Benz(e)aceanthrylene and Benz(l)aceanthrylene in Sencar Mice.
Author Nesnow, S. ; Gold, A. ; Sangaiah, R. ; Triplett, L. L. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Oak Ridge National Lab., TN. Biology Div.
Year Published 1984
Report Number EPA/600/J-84/259;
Stock Number PB85-193738
Additional Subjects Bacteria ; Mutagens ; Environmental surveys ; Aromatic polycyclic hydrocarbons ; Laboratory animals ; Mice ; Carcinogens ; Public health ; Risk ; Neoplasms ; Skin cancer ; Toxicity ; Reprints ; Benzaceanthrylene ; Benzanthracene ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB85-193738 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Benz(e)aceanthrylene and benz(1)aceanthrylene, cyclopenta-fused derivatives of benz(1)anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both PAH induced papilloma formation in the range of 50-1000 nmol/mouse. Benz(1)aceanthrylene was the most active, being approximately 4 times as activeas benzo(a)pyrene while benz(e)aceanthrylene had activity approximately equivalent to benzo(a)pyrene. These results are in contrast to those reported for the air pollutant, cyclopenta(cd)pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. The authors postulate that these cyclopenta-PAH are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAH and that they may be of importance as contributors to air pollution carcinogenesis. (Copyright (c) 1984 Elsevier Scientific Publishers Ireland Ltd.)