||Mouse Skin Tumor-Initiating Activity of Benz(j)aceanthrylene in SENCAR Mice.
Nesnow, S. ;
Gold, A. ;
Sangaiah, R. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Texas Univ. System Cancer Center, Smithville.;Public Health Service, Rockville, MD.
Skin neoplasms ;
Dose-response relationships ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Benz(j)aceanthrylene (B(j)A), a cyclopenta-fused derivative of benz(a)anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T1/2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A/J mice. B(j)A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 micrograms/mouse. B(j)A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 micrograms/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B(j)A is extremely potent. (Copyright (c) 1993 Elsevier Scientific Publishers Ireland Ltd.)