Record Display for the EPA National Library Catalog


Main Title Renal Functional Teratogenesis Resulting from Adriamycin Exposure (Journal Version).
Author Kavlock, R. J. ; Rogers, E. H. ; Rehnberg, B. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1986
Year Published 1986
Report Number EPA/600/J-86/482;
Stock Number PB89-105423
Additional Subjects Toxicity ; Adriamycin ; Teratogens ; Kidney ; Prenatal exposure delayed effects ; Kidney function tests ; Laboratory animals ; Pregnancy ; Exposure ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-105423 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Pregnant Sprague Dawley rats were exposed to adriamycin, an anthracycline antibiotic used in the treatment of neoplasms, and offspring were evaluated for renal functional competence using a variety of physiological techniques. Exposure consisted of 0, 1.0 or 1.5 mg/kg by intraperitoneal injection on either gestational days 7-10 or 10-12. Exposure during days 7-10 of gestation produced greater evidence of overt developmental toxicity than did exposure during days 10-12 of gestation. The reverse was true, however, for the effects of adriamycin on renal function, as the majority of effects on these measures (including decreased creatinine clearance, increased fractional excretion of water, decreased renal concentrating ability and decreased ability to excrete an acid load) were found in the high dose pups exposed during days 10-12 of gestation.